AcneSafe Logo
iS Clinical iS Clinical Super Serum Advance+ - Product image showing packaging and label for comedogenic ingredient analysis
iS ClinicalSerum

iS Clinical Super Serum Advance+

Low Risk(0)
22 ingredients

iS Clinical Super Serum Advance+ is a scientifically advanced, high-performance serum designed to brighten the complexion and reduce the appearance of fine lines and scars. This clinically-proven formula centers around a 15% concentration of L-Ascorbic Acid (Vitamin C), a powerhouse antioxidant that protects against environmental damage while promoting collagen production. Combined with Arbutin and Mushroom Extract, it effectively targets hyperpigmentation and uneven skin tone. The addition of Hyaluronic Acid ensures the skin remains deeply hydrated, while Copper Tripeptide Growth Factors support long-term skin health and rejuvenation. Its texture is incredibly lightweight and fast-absorbing, leaving no greasy or tacky residue behind. This makes it an excellent choice for those who want potent anti-aging and brightening benefits without the heavy feel of traditional creams. Whether you are dealing with post-acne marks, sun damage, or simply looking to revitalize dull skin, this serum offers a sophisticated blend of ingredients that deliver visible results while maintaining a gentle profile for sensitive complexions.

Our Analysis

Our deep-dive ingredient analysis of iS Clinical Super Serum Advance+ yields a LOW comedogenic risk rating. After scanning the full formulation, we found zero flagged ingredients known to clog pores or trigger breakouts. The formula utilizes a clean, water-based delivery system and relies on high-quality actives like Ascorbic Acid and Arbutin. Unlike many anti-aging serums that use heavy oils or synthetic esters to provide slip, this product is formulated to be strictly non-comedogenic. This makes it an exceptionally safe and effective choice for individuals who are prone to congestion or hormonal acne.

Skin Type Recommendations

This serum is highly recommended for all skin types, including oily, combination, and acne-prone. Its lightweight, oil-free texture won't weigh down greasy skin, while Hyaluronic Acid provides essential hydration for dry types. It is particularly beneficial for those with sensitive skin looking to treat hyperpigmentation without the risk of irritation.

Flagged Ingredients

No High-Risk Ingredients

This product does not contain known high-risk comedogenic ingredients.

Want Deeper Analysis?

Run our MACR (Multi-Axis Comedogenic Risk) analysis to get a comprehensive 5-axis risk assessment. This AI-powered analysis evaluates ingredients for Plugging Risk, Barrier Damage, Fungal Acne Risk, Oxidation Risk, and real-world User Reports — giving you personalized scores for your skin type.

Full Ingredient List(22 ingredients)

Water/​Aqua/​EauAscorbic AcidHyaluronic AcidPentylene GlycolArbutinPolyporus Umbellatus (Mushroom) ExtractCalcium PantothenateZinc SulfateUreaGlucoseGuanidine HclTripeptide-1GlycerinPhenoxyethanolAsiaticosideAsiatic AcidMadecassic AcidWater/Aqua/EauRead all the geeky details about Ascorbic Acid here >>Read all the geeky details about Hyaluronic Acid here >>Read all the geeky details about Glycerin here >>[more]

Is Your Routine Acne-Safe?

Do not guess. Instantly check your products for pore-clogging ingredients with our AI-powered tool.

Check Ingredients Now
More from iS Clinical

Other iS Clinical Products

View all →
Serum

Similar Serum

View all →
Low Risk

Similar Risk Level

View all →

Our analysis is powered by AI and backed by extensive research on comedogenic ingredients — but it's not medical advice. For skin concerns, please consult a dermatologist.