NIOD Copper Amino Isolate Serum 2:1 (Discontinued)
NIOD (Non-Invasive Options in Dermal Science) revolutionized the skincare industry with its focus on 'pro-health' rather than just 'anti-aging.' The Copper Amino Isolate Serum 2:1 (CAIS 2:1) was a standout product in this mission, despite now being discontinued. This advanced serum utilized a high concentration of copper peptides to support skin remodeling, manage signs of inflammation, and promote collagen synthesis. Its primary active, Copper Gluconate, is paired with a minimalist delivery system designed to penetrate deeply and efficiently. The texture of CAIS 2:1 is famously watery and thin, often appearing as a vibrant blue liquid in the bottle but absorbing instantly into the skin without leaving any tacky or oily residue. This weightless feel made it a cult favorite for those who prefer lightweight layering in their routines. For users with sensitive or acne-prone skin, this serum represented a sophisticated way to achieve skin repair and radiance without the risk of irritation or pore blockage. It remains a gold standard for technical, ingredient-focused skincare enthusiasts who prioritize long-term skin health over temporary cosmetic fixes.
Our Analysis
Our comprehensive ingredient analysis of the NIOD Copper Amino Isolate Serum 2:1 confirms a LOW comedogenic risk level, making it an exceptional choice for those prone to breakouts. We found zero flagged ingredients in this formulation. The serum relies on a simple, water-based carrier system featuring Isoceteth-20 as a mild emulsifier, which is not known to trigger acne. Because it avoids common triggers like heavy oils, esters, and waxes, it provides the skin with high-performance copper peptides without any fear of congestion. It is a rare example of a potent reparative treatment that is entirely acne-safe.
Skin Type Recommendations
This serum is ideal for all skin types, but it is particularly beneficial for oily, combination, and acne-prone skin due to its weightless, non-clogging formula. Its reparative properties also make it a great option for sensitive skin needing recovery. While safe for dry skin, it should be layered under a non-comedogenic moisturizer for hydration.
Flagged Ingredients
This product does not contain known high-risk comedogenic ingredients.
Want Deeper Analysis?
Run our MACR (Multi-Axis Comedogenic Risk) analysis to get a comprehensive 5-axis risk assessment. This AI-powered analysis evaluates ingredients for Plugging Risk, Barrier Damage, Fungal Acne Risk, Oxidation Risk, and real-world User Reports — giving you personalized scores for your skin type.
