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Zo skin health Zo skin health Ossential® Daily Power Defense (Discontinued) - Product image showing packaging and label for comedogenic ingredient analysis
Zo skin healthRetinol Treatment

Zo skin health Ossential® Daily Power Defense (Discontinued)

Moderate Risk(8)
57 ingredients3 flagged

Zo Skin Health Ossential® Daily Power Defense was a cornerstone antioxidant serum designed to provide comprehensive environmental protection and support the skin's natural repair mechanisms. Formulated by the renowned Dr. Zein Obagi, this serum aimed to strengthen the skin barrier while reducing the appearance of fine lines and wrinkles. Its sophisticated blend included DNA repair enzymes and a stable form of Vitamin E (Tocopherol) to neutralize oxidative stress throughout the day. The texture, driven by siloxanes like Cyclopentasiloxane and Cyclohexasiloxane, offered a lightweight, silky finish that absorbed quickly without leaving a heavy residue. While this specific iteration (Ossential®) has been discontinued and replaced by newer versions, its ingredient profile remains a significant point of interest for those tracking pore-clogging potential. For users with aging or sun-damaged skin, it promised a smoother, more resilient complexion. However, despite its luxurious feel and high-performance claims, those with reactive or acne-prone skin should pay close attention to the specific emollients used to create its signature glide.

Our Analysis

Our analysis of the Zo Skin Health Ossential® Daily Power Defense reveals a moderate comedogenic risk level. The primary concern for acne-prone users is the inclusion of Palm Oil, which carries a high rating of 4/5 due to its high Palmitic Acid content that can create a heavy, pore-clogging film. Additionally, while Cetearyl Alcohol is a common fatty alcohol emollient, it can contribute to congestion in certain formulations. The presence of Tocopherol (Vitamin E) adds a minor risk for those sensitive to thick oils. These ingredients make the formula potentially problematic for those prone to breakouts.

Skin Type Recommendations

This product is best suited for dry, mature, or sun-damaged skin types that require intensive antioxidant support. It is not recommended for oily or acne-prone skin due to the moderate risk of pore clogging from Palm Oil. Individuals with congestion-prone skin should look for the brand's updated, non-comedogenic alternatives.

Flagged Ingredients

4
palm oil

High saturated fat (Palmitic Acid) content creates a heavy, clogging film.

2
cetearyl alcohol

Fatty alcohol emollient with low-moderate comedogenicity on its own. However, when combined with Ceteareth-20, the synergistic effect can significantly increase pore-clogging potential (combined rating of 4).

2
tocopherol

Pure Vitamin E is thick and sticky; safe in small amounts as an antioxidant, but potentially clogging in pure oil form.

Want Deeper Analysis?

Run our MACR (Multi-Axis Comedogenic Risk) analysis to get a comprehensive 5-axis risk assessment. This AI-powered analysis evaluates ingredients for Plugging Risk, Barrier Damage, Fungal Acne Risk, Oxidation Risk, and real-world User Reports — giving you personalized scores for your skin type.

Full Ingredient List(57 ingredients)

Water (Aqua)Cetearyl IsononanoateCyclopentasiloxaneCyclohexasiloxanePentylene GlycolCetearyl AlcoholGlycerinSteareth-20Jojoba EstersCarbomerC14-22 AlcoholsPhenoxyethanolCetearyl GlucosideSafflower Oil/​Palm Oil Aminopropanediol EstersPolysorbate 20Butylene GlycolPalmitoyl OligopeptidePalmitoyl Tetrapeptide-7Sodium HydroxideCaprylyl GlycolC12-20 Alkyl GlucosideEthylhexylglycerinLactoseDisodium EDTACelluloseHexylene GlycolPotassium SorbateBeta-Glucan12-HexanediolMethylparabenLecithinHydroxypropyl MethylcelluloseSorbitolEDTABenzoic AcidSodium BenzoateArabidopsis Thaliana ExtractMicrococcus LysateRetinolRetinyl PalmitateTocopheryl AcetateCitrus Aurantium Dulcis Peel OilCitrus Limon Peel OilCitrus Nobilis Peel OilCitrus Reticulata Peel OilMentha Piperita OilMimosa Tenuiflora Bark ExtractTocopherolLimoneneCi 77007 (Ultramarines)Ci 60730 (Ext. Violet 2)Safflower Oil/Palm Oil Aminopropanediol EstersRead all the geeky details about Glycerin here >>Read all the geeky details about Retinol here >>Read all the geeky details about Tocopherol here >>[more]

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Our analysis is powered by AI and backed by extensive research on comedogenic ingredients — but it's not medical advice. For skin concerns, please consult a dermatologist.