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iS Clinical iS Clinical Pro Heal Serum Advance - Product image showing packaging and label for comedogenic ingredient analysis
iS ClinicalSerum

iS Clinical Pro Heal Serum Advance

Moderate Risk(7)
24 ingredients2 flagged

The iS Clinical Pro Heal Serum Advance is a high-potency antioxidant treatment designed to revitalize and protect compromised skin. Formulated with a powerful 15% concentration of L-Ascorbic Acid (Vitamin C), this serum aims to brighten the complexion, reduce inflammation, and provide superior photoprotection against environmental stressors. The formula is often recommended for those dealing with rosacea, cystic acne, and signs of aging, as it combines healing ingredients like Zinc Sulfate and Olive Leaf Extract. In terms of texture, the serum is incredibly lightweight and watery, thanks to an alcohol-based delivery system that ensures rapid absorption into the skin without leaving a greasy residue. While it provides significant benefits for skin repair and collagen synthesis, the ingredient profile contains specific surfactants that require caution. Users will find it absorbs almost instantly, making it easy to layer under moisturizers, but those with sensitive or clog-prone skin should pay close attention to the specific emulsifiers used to maintain the formula's stability.

Our Analysis

Our analysis of the iS Clinical Pro Heal Serum Advance indicates a MODERATE comedogenic risk level. The most significant concern is the inclusion of Laureth-4, which carries a maximum comedogenic rating of 5/5. This oxidative surfactant is known to potentially trigger inflammatory comedones in pore-clogging prone individuals. Furthermore, the formula contains Tocopherol (Vitamin E), which has a rating of 2/5; while beneficial as an antioxidant, it can be problematic for some skin types when combined with other heavy ingredients. Despite its healing properties, these specific components may lead to congestion for users with active acne.

Skin Type Recommendations

This serum is best suited for mature, sun-damaged, or dry skin types looking for intensive antioxidant protection. However, it is NOT recommended for oily or acne-prone skin due to the high concentration of Laureth-4. Those with sensitive skin should also patch test due to the high Vitamin C and alcohol content.

Flagged Ingredients

5
laureth-4

Oxidative surfactant creating inflammatory comedones.

2
tocopherol

Pure Vitamin E is thick and sticky; safe in small amounts as an antioxidant, but potentially clogging in pure oil form.

Want Deeper Analysis?

Run our MACR (Multi-Axis Comedogenic Risk) analysis to get a comprehensive 5-axis risk assessment. This AI-powered analysis evaluates ingredients for Plugging Risk, Barrier Damage, Fungal Acne Risk, Oxidation Risk, and real-world User Reports — giving you personalized scores for your skin type.

Full Ingredient List(24 ingredients)

Water/​ Aqua/​ EauAscorbic AcidLaureth-4Alcohol Denat.Pentylene GlycolPropylene GlycolOlea Europaea (Olive) Leaf ExtractZinc SulfateTocopherolPolyporus Umbellatus (Mushroom) ExtractArbutinGlycerinBioflavonoidsRetinolPolysorbate 20PhenoxyethanolWater/ Aqua/ EauRead all the geeky details about Ascorbic Acid here >>Read all the geeky details about Alcohol Denat. here >>Read all the geeky details about Propylene Glycol here >>Read all the geeky details about Tocopherol here >>Read all the geeky details about Glycerin here >>Read all the geeky details about Retinol here >>[more]

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Our analysis is powered by AI and backed by extensive research on comedogenic ingredients — but it's not medical advice. For skin concerns, please consult a dermatologist.